Self-assembled sorbitol-derived supramolecular hydrogels for the controlled encapsulation and release of active pharmaceutical ingredients

Edward J Howe; Babatunde O Okesola; David K Smith

doi:10.1039/c5cc01868d

Self-assembled sorbitol-derived supramolecular hydrogels for the controlled encapsulation and release of active pharmaceutical ingredients

Chem Commun (Camb). 2015 May 1;51(35):7451-4. doi: 10.1039/c5cc01868d.

Authors

Edward J Howe¹, Babatunde O Okesola, David K Smith

Affiliation

¹ Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK. david.smith@york.ac.uk.

PMID: 25824859
DOI: 10.1039/c5cc01868d

Abstract

A simple supramolecular hydrogel based on 1,3:2,4-di(4-acylhydrazide)benzylidene sorbitol (DBS-CONHNH2), is able to extract acid-functionalised anti-inflammatory drugs via directed interactions with the self-assembled gel nanofibres. Two-component hydrogel-drug hybrid materials can be easily formed by mixing and exhibit pH-controlled drug release.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Inflammatory Agents / chemistry*
Anti-Inflammatory Agents / metabolism
Benzylidene Compounds / chemistry
Drug Carriers / chemistry*
Drug Liberation
Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry*
Hydrogen-Ion Concentration
Nanofibers / chemistry
Nanofibers / ultrastructure
Sorbitol / chemistry*

Substances

Anti-Inflammatory Agents
Benzylidene Compounds
Drug Carriers
Hydrogel, Polyethylene Glycol Dimethacrylate
Sorbitol