Serum levels of proinflammatory cytokines in painful knee osteoarthritis and sensitization

Marta Imamura; Fernando Ezquerro; Fábio Marcon Alfieri; Lucy Vilas Boas; Tania Regina Tozetto-Mendoza; Janini Chen; Levent Özçakar; Lars Arendt-Nielsen; Linamara Rizzo Battistella

doi:10.1155/2015/329792

Serum levels of proinflammatory cytokines in painful knee osteoarthritis and sensitization

Int J Inflam. 2015:2015:329792. doi: 10.1155/2015/329792. Epub 2015 Mar 2.

Authors

Marta Imamura¹, Fernando Ezquerro², Fábio Marcon Alfieri³, Lucy Vilas Boas⁴, Tania Regina Tozetto-Mendoza⁴, Janini Chen⁵, Levent Özçakar⁶, Lars Arendt-Nielsen⁷, Linamara Rizzo Battistella¹

Affiliations

¹ Clinical Research Center, Institute of Physical Medicine and Rehabilitation, University of São Paulo School of Medicine, Rua Jandiatuba, 580 Vila Andrade, 05716-150 São Paulo, SP, Brazil.
² University of São Paulo School of Medicine, Avenida Dr. Arnaldo, 455 Cerqueira César, 01246903 São Paulo, SP, Brazil.
³ Clinical Research Center, Institute of Physical Medicine and Rehabilitation, University of São Paulo School of Medicine, Rua Jandiatuba, 580 Vila Andrade, 05716-150 São Paulo, SP, Brazil ; São Paulo Adventist University Center, Estrada de Itapecerica, 5859 Jardim IAE, 05858-001 São Paulo, SP, Brazil.
⁴ Tropical Hematology Laboratory, Institute of Tropical Medicine of São Paulo and Medical Research Laboratory, LIM 52, University of São Paulo, Avenida Dr. Arnaldo, 455 Cerqueira César, 01246903 São Paulo, SP, Brazil.
⁵ Institute of Physical Medicine and Rehabilitation, University of São Paulo School of Medicine, Rua Domingo de Soto 100, Vila Mariana, 04116-030 São Paulo, SP, Brazil.
⁶ Department of Physical Medicine and Rehabilitation, Hacettepe University Medical School, Hacettepe University Faculty of Medicine, Sıhhiye, 06100 Ankara, Turkey.
⁷ Center for Sensory-Motor Interaction, School of Medicine, Aalborg University, Fredrik Bajers Vej 7, Building D3, 9220 Aalborg E, Denmark.

Abstract

Osteoarthritis (OA) is the most common joint disorder in the world. Among the mechanisms involved in osteoarthritis, biomarkers (cytokines profile) may be related to pain and pain intensity, functional capacity, and pressure pain thresholds (PPT). Thus, the study of these relationships may offer useful information about pathophysiology and associated mechanisms involved in osteoarthritis. Therefore, the objective of this study was to investigate the seric concentration of pro (IL-6, IL-8, and TNF-α) and anti-inflammatory (IL-10) cytokines in patients with painful knee osteoarthritis and to correlate the levels of these biomarkers with the patients' functional capacity and pressure pain threshold (PPT) values.