Pustular drug hypersensitivity syndrome due to allopurinol

Chaker Ben Salem; Wafa Saidi; Sofiene Larif; Neila Fathallah; Raoudha Slim; Houssem Hmouda

doi:10.4103/0253-7613.150378

Pustular drug hypersensitivity syndrome due to allopurinol

Indian J Pharmacol. 2015 Jan-Feb;47(1):123-4. doi: 10.4103/0253-7613.150378.

Authors

Chaker Ben Salem¹, Wafa Saidi², Sofiene Larif¹, Neila Fathallah¹, Raoudha Slim¹, Houssem Hmouda¹

Affiliations

¹ Department of Pharmacology, Faculty of Medicine of Sousse, Tunisia.
² Department of Dermatology, Farhat Hached University Hospital, Tunisia.

Abstract

Allopurinol hypersensitivity syndrome (AHS) is a severe drug reaction. It is characterized by rash, fever, and internal organ involvement. It may present in different clinical forms. We present a case of acute generalized exanthematous pustulosis occurring as a manifestation of AHS.

Keywords: Allopurinol; hypersensitivity syndrome; pustulosis.

Publication types

Case Reports

MeSH terms

Acute Generalized Exanthematous Pustulosis / diagnosis
Acute Generalized Exanthematous Pustulosis / drug therapy
Acute Generalized Exanthematous Pustulosis / etiology*
Adrenal Cortex Hormones / therapeutic use
Aged
Allopurinol / adverse effects*
Biopsy
Gout Suppressants / adverse effects*
Humans
Hyperuricemia / diagnosis
Hyperuricemia / drug therapy*
Male
Skin / drug effects*
Skin / pathology
Treatment Outcome

Substances

Adrenal Cortex Hormones
Gout Suppressants
Allopurinol