Sildenafil as a therapeutic option for digital ischemic ulceration: case report

J Hand Surg Am. 2015 May;40(5):890-3. doi: 10.1016/j.jhsa.2015.01.041. Epub 2015 Mar 25.

Abstract

We report the case of a 37-year-old woman who developed critical upper limb ischemia caused by a cervical rib. Because the malformation was initially undiagnosed, a vascular bypass was performed, and failure occurred. Following a 6-month therapy with sildenafil, revascularization of the arm was successful and amputation was avoided. A 6-year follow-up shows a rich collateral network at the compression site and normal values of digital plethysmography. Because hand surgeons often see patients with digital ulcerations and other manifestations of peripheral vascular pathology, therapy of ischemia with sildenafil could be an effective treatment option in patients not responding to classic drugs.

Keywords: Cervical rib; digital necrosis; sildenafil; thoracic outlet syndrome; unilateral Raynaud phenomenon.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Arm / blood supply*
  • Female
  • Humans
  • Ischemia / drug therapy*
  • Ischemia / etiology
  • Necrosis
  • Peripheral Vascular Diseases / drug therapy*
  • Peripheral Vascular Diseases / etiology
  • Sildenafil Citrate / therapeutic use*
  • Skin Ulcer / drug therapy*
  • Skin Ulcer / etiology
  • Thoracic Outlet Syndrome / complications*
  • Vasodilator Agents / therapeutic use*

Substances

  • Vasodilator Agents
  • Sildenafil Citrate