Transcriptional mimicry by tumor-associated stroma

Hoon Kim; Roel G W Verhaak

doi:10.1038/ng.3255

Transcriptional mimicry by tumor-associated stroma

Nat Genet. 2015 Apr;47(4):307-9. doi: 10.1038/ng.3255.

Authors

Hoon Kim¹, Roel G W Verhaak²

Affiliations

¹ Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
² 1] Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. [2] Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

PMID: 25814306
DOI: 10.1038/ng.3255

Abstract

Recent molecular classification of colorectal cancer (CRC) has identified a poor-prognosis transcriptional subtype associated with mesenchymal traits. New studies used CRC transcriptomic data to show that tumor-associated stroma mimics the gene signature of epithelial-to-mesenchymal transition (EMT) and found no evidence for EMT of colorectal tumor cells.

MeSH terms

Colorectal Neoplasms / diagnosis
Colorectal Neoplasms / genetics*
Colorectal Neoplasms / pathology*
Disease Progression
Epithelial-Mesenchymal Transition / genetics
Gene Expression Regulation, Neoplastic
Humans
Neoplastic Stem Cells / metabolism
Neoplastic Stem Cells / pathology
Prognosis
Stromal Cells / metabolism
Stromal Cells / pathology
Transcriptome*

Abstract

MeSH terms

Grants and funding