Physiology of the Renal Interstitium

Clin J Am Soc Nephrol. 2015 Oct 7;10(10):1831-40. doi: 10.2215/CJN.00640114. Epub 2015 Mar 26.

Abstract

Long overlooked as the virtual compartment and then strictly characterized through descriptive morphologic analysis, the renal interstitium has finally been associated with function. With identification of interstitial renin- and erythropoietin-producing cells, the most prominent endocrine functions of the kidney have now been attributed to the renal interstitium. This article reviews the functional role of renal interstitium.

Keywords: erythropoietin; fibroblast; fibrosis; renal interstitium; renin angiotensin system.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine / metabolism
  • Anemia / etiology
  • Anemia / metabolism*
  • Animals
  • Erythropoietin / biosynthesis*
  • Fibroblasts / metabolism*
  • Fibroblasts / physiology
  • Humans
  • Kidney / cytology*
  • Kidney / embryology
  • Kidney / physiology*
  • Kidney / ultrastructure
  • Kidney Diseases / physiopathology
  • Mesenchymal Stem Cells
  • Neural Crest
  • Renin / metabolism
  • Renin-Angiotensin System / physiology

Substances

  • EPO protein, human
  • Erythropoietin
  • Renin
  • Adenosine