Abstract
A novel series of C-nucleosides, featuring the presence of a 1,2,3-triazole ring linked to an isoxazolidine system, has been designed as mimetics of the pyrimidine nucleobases. An antiproliferative effect was observed for compounds 17a and 17b: the growth inhibitory effect reaches the 50% in HepG2 and HT-29 cells and increases up to 56% in the SH-SY5Y cell line after 72 h of incubation at a 100 µM concentration.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Proliferation / drug effects
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Drug Screening Assays, Antitumor
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HT29 Cells
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Hep G2 Cells
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Humans
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Isoxazoles / chemical synthesis*
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Isoxazoles / chemistry
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Isoxazoles / pharmacology*
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Molecular Mimicry
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Molecular Structure
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Nucleosides / chemical synthesis
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Nucleosides / chemistry
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Nucleosides / pharmacology
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Pyrimidines / chemistry
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Isoxazoles
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Nucleosides
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Pyrimidines
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pyrimidine