Establishment of Four New Human Primary Cell Cultures from Chemo-Naïve Italian Osteosarcoma Patients

Marcella Laschi; Giulia Bernardini; Michela Geminiani; Lorenzo Ghezzi; Loredana Amato; Daniela Braconi; Lia Millucci; Bruno Frediani; Adriano Spreafico; Alessandro Franchi; Domenico Campanacci; Rodolfo Capanna; Annalisa Santucci

doi:10.1002/jcp.24996

Establishment of Four New Human Primary Cell Cultures from Chemo-Naïve Italian Osteosarcoma Patients

J Cell Physiol. 2015 Nov;230(11):2718-27. doi: 10.1002/jcp.24996.

Affiliations

¹ Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Siena, Italy.
² Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, Università degli Studi di Siena, Policlinico Le Scotte, Siena, Italy.
³ Immunoematologia Trasfusionale, Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte, Siena, Italy.
⁴ Dipartimento di Chirurgia e Medicina Traslazionale, Università degli Studi di Firenze, Firenze, Italy.
⁵ Dipartimento di Ortopedia, Oncologica e Chirurgia Ricostruttiva, Azienda Ospedaliera Universitaria Careggi, Florence, Italy.

PMID: 25809010
DOI: 10.1002/jcp.24996

Abstract

Osteosarcoma (OS) is a primary highly malignant tumor of bone, affecting predominately adolescents and young adults between 10 and 20 years of age. OS is characterized by an extremely aggressive clinical course, with a rapid development of metastasis to the lung and distant bones.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Cell Line, Tumor*
Female
Humans
Italy
Male
Osteosarcoma / drug therapy
Osteosarcoma / pathology*
Primary Cell Culture*
Young Adult

Grants and funding

GGP10058/TI_/Telethon/Italy