Nitric oxide releasing plasma polymer coating with bacteriostatic properties and no cytotoxic side effects

Thomas D Michl; Bryan R Coad; Michael Doran; Michael Osiecki; Morteza Hasanzadeh Kafshgari; Nicolas H Voelcker; Amanda Hüsler; Krasimir Vasilev; Hans J Griesser

doi:10.1039/c5cc01722j

Nitric oxide releasing plasma polymer coating with bacteriostatic properties and no cytotoxic side effects

Chem Commun (Camb). 2015 Apr 25;51(32):7058-60. doi: 10.1039/c5cc01722j. Epub 2015 Mar 25.

Authors

Thomas D Michl¹, Bryan R Coad, Michael Doran, Michael Osiecki, Morteza Hasanzadeh Kafshgari, Nicolas H Voelcker, Amanda Hüsler, Krasimir Vasilev, Hans J Griesser

Affiliation

¹ Ian Wark Research Institute, University of South Australia, Mawson Lakes, SA 5095, Australia. mictd002@mymail.unisa.edu.au.

PMID: 25807345
DOI: 10.1039/c5cc01722j

Abstract

We report a stable plasma polymer coating, using isopentyl nitrite as a volatile precursor, which releases nitric oxide at bacteriostatic concentrations when contacted with water, inhibiting bacterial growth without cytotoxic side effects to human mesenchymal stem/stromal cells.

MeSH terms

Anti-Bacterial Agents / adverse effects
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Drug Carriers / chemistry*
Drug Liberation*
Humans
Nitric Oxide / chemistry*
Plasma Gases / chemistry*
Polymers / adverse effects
Polymers / chemistry*
Polymers / pharmacology*

Substances

Anti-Bacterial Agents
Drug Carriers
Plasma Gases
Polymers
Nitric Oxide