Association of the metformin with the risk of lung cancer: a meta-analysis

Li Wang; Yong Song; Guan-Nan Wu; Dong-Mei Yuan

doi:10.3978/j.issn.2218-6751.2013.08.01

Association of the metformin with the risk of lung cancer: a meta-analysis

Transl Lung Cancer Res. 2013 Aug;2(4):259-63. doi: 10.3978/j.issn.2218-6751.2013.08.01.

Authors

Li Wang¹, Yong Song¹, Guan-Nan Wu¹, Dong-Mei Yuan¹

Affiliation

¹ Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, P. R. China.

PMID: 25806241
PMCID: PMC4367614
DOI: 10.3978/j.issn.2218-6751.2013.08.01

Abstract

Objective: To assess the correlation between metformin and risk of developing lung cancer by meta-analysis.

Methods: Papers on the correlation between metformin and risk of lung cancer were searched from PubMed, MEDLINE, EMBASE, ISI Web of Science, and Cochrane Library.

Results: Six papers on case-control study were included in this study, involving 39,787 metformin users and 177,752 controls. Meta-analysis showed that the risk of developing lung cancer was lower in metformin users than in those without metformin (OR=0.55, 95% CI: 0.35-0.85, P<0.001).

Conclusions: The risk of developing lung cancer is lower in metformin users than in those without metformin.

Keywords: Metformin; lung cancer; meta-analysis.