ISG15 uncut: Dissecting enzymatic and non-enzymatic functions of USP18 in vivo

Lars Ketscher; Klaus-Peter Knobeloch

doi:10.1016/j.cyto.2015.03.006

ISG15 uncut: Dissecting enzymatic and non-enzymatic functions of USP18 in vivo

Cytokine. 2015 Dec;76(2):569-571. doi: 10.1016/j.cyto.2015.03.006. Epub 2015 Mar 21.

Authors

Lars Ketscher¹, Klaus-Peter Knobeloch²

Affiliations

¹ R&D LGCR, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany.
² Institute of Neuropathology, University of Freiburg, 79106 Freiburg, Germany. Electronic address: Klaus-Peter.Knobeloch@uniklinik-freiburg.de.

PMID: 25805508
DOI: 10.1016/j.cyto.2015.03.006

Abstract

Posttranslational protein modification by ISG15 plays an important role in antiviral defense. We selectively inactivated the ISG15 isopeptidase activity of USP18 in mice. Increased ISGylation was accompanied by enhanced viral resistance without causing detrimental side effects suggesting that USP18 protease inhibition might be a suitable antiviral strategy.

Keywords: ISG15; Interferon; Stat1; USP18; Virus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cytokines / metabolism*
Mice
Protein Processing, Post-Translational
Ubiquitin Thiolesterase / metabolism*
Ubiquitins / metabolism

Substances

Cytokines
G1p2 protein, mouse
Ubiquitins
Usp18 protein, mouse
Ubiquitin Thiolesterase