Bioactive carbazole alkaloids from the stems of Clausena lansium

Fitoterapia. 2015 Jun:103:122-8. doi: 10.1016/j.fitote.2015.03.018. Epub 2015 Mar 21.

Abstract

Seven new carbazole alkaloids, claulansines L-R (1-7), and six known analogues (8-13) were isolated from the stems of Clausena lansium. Their structures were elucidated on the basis of spectroscopic analyses, including UV, IR, and NMR experiments (HSQC, HMBC, and NOE experiment). Compound 7 showed moderate anti-inflammatory activities. Compounds 3, 5, 6, 8, and 12 exhibited moderate hepatoprotective activities.

Keywords: Anti-inflammatory; Claulansine L-R; Clausena lansium; Hepatoprotective.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology*
  • Animals
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology*
  • Carbazoles / isolation & purification
  • Carbazoles / pharmacology*
  • Cell Line
  • Clausena / chemistry*
  • Hep G2 Cells / drug effects
  • Humans
  • Mice
  • Molecular Structure
  • Nitric Oxide / metabolism
  • Plant Stems / chemistry

Substances

  • Alkaloids
  • Anti-Inflammatory Agents
  • Carbazoles
  • carbazole
  • Nitric Oxide