Facile Synthesis, Characterization, and In Vitro Antimicrobial Screening of a New Series of 2,4,6-Trisubstituted-s-triazine Based Compounds

Ravi Bhushan Singh; Nirupam Das; Md Kamaruz Zaman

doi:10.1155/2015/571836

Facile Synthesis, Characterization, and In Vitro Antimicrobial Screening of a New Series of 2,4,6-Trisubstituted-s-triazine Based Compounds

Int J Med Chem. 2015:2015:571836. doi: 10.1155/2015/571836. Epub 2015 Jan 31.

Authors

Ravi Bhushan Singh¹, Nirupam Das², Md Kamaruz Zaman³

Affiliations

¹ Institute of Pharmacy, Harish Chandra PG College, Varanasi 221 002, India.
² Department of Pharmaceutical Sciences, Assam University, Silchar 788 011, India.
³ Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh 786 004, India.

Abstract

A series of new 2,4,6-trisubstituted-s-triazine was synthesized, assessed for antimicrobial activity, and characterized by FTIR, (1)HNMR, (13)CNMR, and elemental analysis. The tested compounds, 4d, 4g, 4h, 4k, and 4n, have shown considerable in vitro antibacterial efficacy with reference to the standard drug ciprofloxacin (MIC 3.125 μgmL(-1) against B. subtilis, E. coli, and K. pneumoniae). It was observed that compounds 4d and 4h displayed equipotent antibacterial efficacy against B. subtilis (MIC 3.125 μgmL(-1)) and S. aureus (MIC 6.25 μgmL(-1)). The studies demonstrated that the para-fluorophenylpiperazine substituted s-triazine (4n) was potent and exhibited broad spectrum antibacterial activity against S. epidermidis, K. pneumoniae, and P. aeruginosa with MIC of 6.25 μgmL(-1) and for E. coli, it showed an MIC of 3.125 μgmL(-1) equipotent with reference to the standard drug. Among all the compounds under investigation, compound 4g also demonstrated significant antifungal activity (3.125 μgmL(-1)) against C. albicans.