Rolling the Genetic Dice: Neutral and Deleterious Smoothened Mutations in Drug-Resistant Basal Cell Carcinoma

J Invest Dermatol. 2015 Aug;135(8):2138-2141. doi: 10.1038/jid.2015.115. Epub 2015 Mar 24.

Authors

Scott X Atwood¹, Kavita Y Sarin¹, Jiang R Li¹, Catherine Y Yao¹, Nicole M Urman¹, Anne Lynn S Chang¹, Jean Y Tang¹, Anthony E Oro²

Affiliations

¹ Department of Dermatology and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.
² Department of Dermatology and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA. Electronic address: oro@stanford.edu.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma, Basal Cell / genetics*
Drug Resistance, Neoplasm / genetics*
Genetic Variation
Genome-Wide Association Study
Hedgehog Proteins / genetics
Humans
Mutation / genetics*
Skin Neoplasms / genetics*
Transcription Factors / genetics
Zinc Finger Protein GLI1

Substances

GLI1 protein, human
Hedgehog Proteins
Transcription Factors
Zinc Finger Protein GLI1

Grants and funding