Epigenetic changes in BRCA1-mutated familial breast cancer

Cancer Genet. 2015 May;208(5):237-40. doi: 10.1016/j.cancergen.2015.02.001. Epub 2015 Feb 13.

Abstract

Familial breast cancer occurs in about 10% of breast cancer cases. Germline mutation in BRCA1 is the most penetrant predisposition for the disease. Mutated BRCA1 leads to disease by causing genome instability via multiple mechanisms including epigenetic changes. This review summarizes recent progress in studying the correlation between BRCA1 predisposition and epigenetic alterations in BRCA1-type familial breast cancer.

Keywords: BRCA1; autosomal dominant; epigenetic alteration; familial breast cancer; germline mutation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • BRCA1 Protein / genetics*
  • Breast Neoplasms / genetics
  • DNA Methylation / genetics*
  • Epigenesis, Genetic / genetics*
  • Female
  • Genetic Predisposition to Disease
  • Genomic Instability
  • Germ-Line Mutation / genetics
  • Humans
  • MicroRNAs / genetics
  • Promoter Regions, Genetic / genetics

Substances

  • BRCA1 Protein
  • BRCA1 protein, human
  • MicroRNAs

Supplementary concepts

  • Breast Cancer, Familial