Cancer cells exhibit altered glucose metabolism characterized by a preference for aerobic glycolysis even when the oxygen content is normal, a phenomenon termed "Warburg effect". However the definite molecular mechanisms of Warburg effect remains unclear, recent works indicated that it might be related to the abnormal activity of the oncogene and tumor suppressor genes, also the change of tumor microenvironment, the abnormal expression of glucose metabolic enzyme and so on. Warburg effect has a relationship with tumor progression and provide suitable conditions for tumor metastasis. This review will summarizes the mechanism of Warburg effect and its effect on tumor metastasis.
肿瘤细胞葡萄糖代谢的一个特点就是在氧含量正常的情况下依然选择利用糖酵解，即Warburg效应。Warburg效应的内在机制十分复杂，可能与癌基因激活、抑癌基因失活，糖代谢酶表达异常和肿瘤微环境改变等有关，具体的机制还有待进一步研究。Warburg效应这种代谢重编程与肿瘤的发生发展有着密切联系，为肿瘤细胞提供生长优势，帮助其逃避凋亡，同时为肿瘤的转移创造合适的环境，促进肿瘤转移。本文概述了Warburg效应的发生机制及其对肿瘤转移的作用。.