Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives-a position statement from the European Society for Blood and Marrow Transplantation (EBMT)

M Mohty; F Malard; M Abecassis; E Aerts; A S Alaskar; M Aljurf; M Arat; P Bader; F Baron; A Bazarbachi; D Blaise; F Ciceri; S Corbacioglu; J-H Dalle; R F Duarte; T Fukuda; A Huynh; T Masszi; M Michallet; A Nagler; M NiChonghaile; T Pagluica; C Peters; F B Petersen; P G Richardson; T Ruutu; B N Savani; E Wallhult; I Yakoub-Agha; E Carreras

doi:10.1038/bmt.2015.52

Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives-a position statement from the European Society for Blood and Marrow Transplantation (EBMT)

Bone Marrow Transplant. 2015 Jun;50(6):781-9. doi: 10.1038/bmt.2015.52. Epub 2015 Mar 23.

Authors

M Mohty¹, F Malard¹, M Abecassis², E Aerts³, A S Alaskar⁴, M Aljurf⁵, M Arat⁶, P Bader⁷, F Baron⁸, A Bazarbachi⁹, D Blaise¹⁰, F Ciceri¹¹, S Corbacioglu¹², J-H Dalle¹³, R F Duarte¹⁴, T Fukuda¹⁵, A Huynh¹⁶, T Masszi¹⁷, M Michallet¹⁸, A Nagler¹⁹, M NiChonghaile²⁰, T Pagluica²¹, C Peters²², F B Petersen²³, P G Richardson²⁴, T Ruutu²⁵, B N Savani²⁶, E Wallhult²⁷, I Yakoub-Agha²⁸, E Carreras²⁹

Affiliations

¹ Hematology department, Hôpital Saint-Antoine, and Université Pierre & Marie Curie, Paris, France.
² Inst Portugues Oncologia, Lisboa, Portugal.
³ Department of Haematology, University Hospital Zurich, Zurich, Switzerland.
⁴ King Abdullah International Medical Research Center/King Saud Bin Abdulaziz University for Health Sciences, Department of Oncology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
⁵ King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
⁶ Sisli Florence Nightingale Hospital, HSCT Unit, Istanbul, Turkey.
⁷ Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University, Frankfurt/Main, Germany.
⁸ Department of Hematology, University of Liege, Liege, Belgium.
⁹ Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.
¹⁰ Blood and Marrow Transplantation Program, Hematology Department, Institut Paoli-Calmettes, Marseille, France.
¹¹ Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy.
¹² Department of Hematology, Oncology, and Stem Cell Transplantation, University of Regensburg, Regensburg, Germany.
¹³ Department of Hematology and Immunology, Hospital Robert Debre, Paris 7-Paris Diderot University, Paris, France.
¹⁴ Department of Haematology, Institut Català d'Oncología (ICO) - Hospital Duran i Reynals, Hospitalet de Llobregat, Barcelona, Spain.
¹⁵ HSCT division, National Cancer Center Hospital, Tokyo, Japan.
¹⁶ Hematology department, Institut Universitaire du Cancer Toulouse - Oncopole, Toulouse, France.
¹⁷ Department of Hematology and Stem Cell Transplantation, St. Istvan and St. Laszlo Hospital, Budapest 3 Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
¹⁸ Hematology Department, Groupement Hospitalier Sud, Hospices Civils de Lyon, Université Claude Bernard Lyon EST, Pierre Bénite, France.
¹⁹ Hematology and Bone Marrow Transplantation, Chaim Sheba Medical center, Tel-Hashomer, Israel.
²⁰ National Stem Cell Transplant Unit (Adults), Department of Haematology, St James's Hospital and Academic Department of Haematology, Trinity College Dublin, Dublin, Ireland.
²¹ Department of Haematology, King's College Hospital, London, UK.
²² Department of Pediatrics, St. Anna Kinderspital, Vienna, Austria.
²³ LDS Hospital, Salt Lake City, UT, USA.
²⁴ Division of Hematologic Malignancy, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
²⁵ Comprehensive Cancer Center, Helsinki University Central Hospital, Helsinki, Finland.
²⁶ Hematology and Stem Cell Transplantation Section, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center and Veterans Affairs Medical Center, Nashville, TN, USA.
²⁷ Section of Haematology and Coagulation, Department of Internal Medicine, Sahlgrenska University Hospital, Göteborg, Sweden.
²⁸ Bone Marrow Transplantation Unit, CHU de Lille, Lille, France.
²⁹ 1] Josep Carreras Leukaemia Research Institute, Barcelona, Spain [2] Haematology Department, Hospital Clinic, Barcelona, Spain [3] Spanish Bone Marrow Donor Program, Josep Carreras Foundation, Barcelona, Spain.

Abstract

Sinusoidal obstruction syndrome or veno-occlusive disease (SOS/VOD) is a potentially life-threatening complication of hematopoietic SCT (HSCT). This review aims to highlight, on behalf of the European Society for Blood and Marrow Transplantation, the current knowledge on SOS/VOD pathophysiology, risk factors, diagnosis and treatments. Our perspectives on SOS/VOD are (i) to accurately identify its risk factors; (ii) to define new criteria for its diagnosis; (iii) to search for SOS/VOD biomarkers and (iv) to propose prospective studies evaluating SOS/VOD prevention and treatment in adults and children.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adult
Biomarkers / blood
Hematopoietic Stem Cell Transplantation / adverse effects*
Humans
Postoperative Complications* / blood
Postoperative Complications* / diagnosis
Postoperative Complications* / physiopathology
Postoperative Complications* / therapy
Risk Factors
Vascular Diseases* / blood
Vascular Diseases* / diagnosis
Vascular Diseases* / etiology
Vascular Diseases* / physiopathology
Vascular Diseases* / therapy

Substances

Biomarkers