Post-transplant molecularly defined Burkitt lymphomas are frequently MYC-negative and characterized by the 11q-gain/loss pattern

Haematologica. 2015 Jul;100(7):e275-9. doi: 10.3324/haematol.2015.124305. Epub 2015 Mar 20.

Authors

Julio Finalet Ferreiro¹, Julie Morscio², Daan Dierickx³, Lukas Marcelis², Gregor Verhoef³, Peter Vandenberghe¹, Thomas Tousseyn², Iwona Wlodarska⁴

Affiliations

¹ KU Leuven, University of Leuven, Center for Human Genetics, Belgium.
² KU Leuven, University of Leuven, Translational Cell and Tissue Research and KU Leuven, University Hospitals Leuven, Department of Pathology, Belgium.
³ KU Leuven, University Hospitals Leuven, Department of Hematology, Belgium.
⁴ KU Leuven, University of Leuven, Center for Human Genetics, Belgium iwona.wlodarska@uzleuven.be.

No abstract available

Keywords: 11q; Burkitt lymphoma; PTLD; post-transplant lymphoproliferative disease.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

1-Alkyl-2-acetylglycerophosphocholine Esterase / genetics
1-Alkyl-2-acetylglycerophosphocholine Esterase / metabolism
Adolescent
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols*
B-Lymphocytes / metabolism
B-Lymphocytes / pathology
Burkitt Lymphoma / drug therapy
Burkitt Lymphoma / etiology
Burkitt Lymphoma / genetics*
Burkitt Lymphoma / mortality
Chromosomes, Human, Pair 11
Cyclophosphamide
Doxorubicin
Epstein-Barr Virus Infections / drug therapy
Epstein-Barr Virus Infections / etiology
Epstein-Barr Virus Infections / genetics*
Epstein-Barr Virus Infections / mortality
Gene Expression Regulation, Neoplastic*
Gene Regulatory Networks
Heart Transplantation / adverse effects
Humans
Immunosuppression Therapy / adverse effects
Kidney Transplantation / adverse effects
Liver Transplantation / adverse effects
Male
Microtubule-Associated Proteins / genetics
Microtubule-Associated Proteins / metabolism
Middle Aged
Mutation
Prednisone
Proto-Oncogene Protein c-ets-1 / genetics
Proto-Oncogene Protein c-ets-1 / metabolism
Proto-Oncogene Protein c-fli-1 / genetics
Proto-Oncogene Protein c-fli-1 / metabolism
Proto-Oncogene Proteins c-myc / genetics
Rituximab / therapeutic use
Signal Transduction
Survival Analysis
Translocation, Genetic*
Vincristine

Substances

ETS1 protein, human
FLI1 protein, human
MYC protein, human
Microtubule-Associated Proteins
Proto-Oncogene Protein c-ets-1
Proto-Oncogene Protein c-fli-1
Proto-Oncogene Proteins c-myc
Rituximab
Vincristine
Doxorubicin
Cyclophosphamide
1-Alkyl-2-acetylglycerophosphocholine Esterase
PAFAH1B2 protein, human
Prednisone

Supplementary concepts

CHOP protocol