Lipases: Valuable catalysts for dynamic kinetic resolutions

Amanda S de Miranda; Leandro S M Miranda; Rodrigo O M A de Souza

doi:10.1016/j.biotechadv.2015.02.015

Lipases: Valuable catalysts for dynamic kinetic resolutions

Biotechnol Adv. 2015 Sep-Oct;33(5):372-93. doi: 10.1016/j.biotechadv.2015.02.015. Epub 2015 Mar 17.

Authors

Amanda S de Miranda¹, Leandro S M Miranda², Rodrigo O M A de Souza²

Affiliations

¹ Laboratory of Biocatalysis and Organic Synthesis, Universidade Federal do Rio de Janeiro, Instituto de Química, Cidade Universitária, Rio de Janeiro CEP21941909, Brazil. Electronic address: a.s.miranda@hotmail.com.
² Laboratory of Biocatalysis and Organic Synthesis, Universidade Federal do Rio de Janeiro, Instituto de Química, Cidade Universitária, Rio de Janeiro CEP21941909, Brazil.

PMID: 25795055
DOI: 10.1016/j.biotechadv.2015.02.015

Abstract

Dynamic kinetic resolutions have proven to be a useful method for the preparation of enantiopure compounds from racemates, leading to the formation of a single enantiomer in theoretically 100% yield. Because lipases are ubiquitous, versatile, stereoselective and robust biocatalysts, they have been successfully applied as co-catalysts in these reactions, being mostly combined with metals in the chemoenzymatic dynamic kinetic resolutions of alcohols and amines.

Keywords: Chemoenzymatic synthesis; Dynamic kinetic resolution; Enantioselectivity; Enzyme catalysis; Lipases; Racemization.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biocatalysis
Biotechnology
Kinetics
Lipase*
Stereoisomerism

Substances

Lipase