Synthesis of C-arylnucleoside analogues

Christophe Len; Gérald Enderlin

doi:10.3390/molecules20034967

Synthesis of C-arylnucleoside analogues

Molecules. 2015 Mar 18;20(3):4967-97. doi: 10.3390/molecules20034967.

Authors

Christophe Len^{1

2}, Gérald Enderlin³

Affiliations

¹ Sorbonne Universités, Université de Technologie de Compiègne, Ecole Supérieure de Chimie Organique et Minérale, Transformations Intégrées de la Matière Renouvelable, Centre de Recherche Royallieu, CS 60319, Compiègne cedex F-60203, France. christophe.len@utc.fr.
² Department of Chemistry, University of Hull, Hull HU6 7RX, UK. christophe.len@utc.fr.
³ Sorbonne Universités, Université de Technologie de Compiègne, Ecole Supérieure de Chimie Organique et Minérale, Transformations Intégrées de la Matière Renouvelable, Centre de Recherche Royallieu, CS 60319, Compiègne cedex F-60203, France. g.enderlin@escom.fr.

Abstract

Modified nucleoside analogues are of great biological importance as antiviral and antitumoral agents. There is special interest in the preparation of C-aryl nucleosides with an aromatic ring in different positions of the glycone for their biological activity. Different chemical synthesis strategies for these targets are described in this review.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Antiviral Agents / chemical synthesis
Antiviral Agents / chemistry
Antiviral Agents / pharmacology
Heterocyclic Compounds / chemical synthesis
Heterocyclic Compounds / chemistry
Heterocyclic Compounds / pharmacology
Molecular Structure
Nucleosides / chemical synthesis*
Nucleosides / chemistry*
Nucleosides / pharmacology
Structure-Activity Relationship

Substances

Antineoplastic Agents
Antiviral Agents
Heterocyclic Compounds
Nucleosides