Increased risk of dementia among patients with pulmonary tuberculosis: a retrospective population-based cohort study

Yi-Hao Peng; Chih-Yu Chen; Ching-Hua Su; Chih-Hsin Muo; Kuan-Fei Chen; Wei-Chih Liao; Chia-Hung Kao

doi:10.1177/1533317515577186

Increased risk of dementia among patients with pulmonary tuberculosis: a retrospective population-based cohort study

Am J Alzheimers Dis Other Demen. 2015 Sep;30(6):629-34. doi: 10.1177/1533317515577186. Epub 2015 Mar 18.

Authors

Yi-Hao Peng¹, Chih-Yu Chen², Ching-Hua Su³, Chih-Hsin Muo⁴, Kuan-Fei Chen⁵, Wei-Chih Liao⁶, Chia-Hung Kao⁷

Affiliations

¹ Department of Respiratory Therapy, China Medical University Hospital, Taichung, Taiwan Department of Respiratory Therapy, China Medical University, Taichung, Taiwan.
² Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University Hospital, Taichung, Taiwan.
³ Section of Respiratory Therapy, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan.
⁴ Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
⁵ Department of Neurology, China Medical University Hospital, Taichung, Taiwan Department of Neurology, China Medical University Beigang Hospital, Yunlin, Taiwan.
⁶ Department of Respiratory Therapy, China Medical University, Taichung, Taiwan Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University Hospital, Taichung, Taiwan.
⁷ Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan d10040@mail.cmuh.org.tw.

Abstract

Objective: We investigated and compared the risk of dementia development in a cohort of patients with tuberculosis (TB).

Methods: The study involved 6473 patient with newly diagnosed TB, and each patient was randomly frequency matched with 4 people without TB based on age, sex, and index year. The risk of dementia development was analyzed using Cox proportional hazards regression.

Results: Among the patients with TB, the overall risk of developing dementia was 1.21-fold significantly higher than the non-TB cohort. In the stratified analysis of dementia risks, only the patients with TB who were male or 50 to 64 years of age exhibited a significantly higher risk of dementia development compared with those without TB. An analysis of the follow-up duration revealed that patients with TB had a 1.78-fold increased risk within 1 year of follow-up.

Conclusion: Patients with TB have a significantly higher risk of developing dementia than that of the general population.

Keywords: cohort study; comorbidity; dementia; tuberculosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Comorbidity*
Databases, Factual / statistics & numerical data
Dementia / epidemiology*
Female
Follow-Up Studies
Humans
Male
Middle Aged
National Health Programs / statistics & numerical data*
Retrospective Studies
Risk
Taiwan / epidemiology
Tuberculosis, Pulmonary / epidemiology*
Young Adult