Ni-catalyzed highly chemo-, regio-, and enantioselective decarboxylative aldol reaction of β,γ-unsaturated α-ketoesters with β-ketoacids

Ai-Jia Wei; Jing Nie; Yan Zheng; Jun-An Ma

doi:10.1021/jo502741z

Ni-catalyzed highly chemo-, regio-, and enantioselective decarboxylative aldol reaction of β,γ-unsaturated α-ketoesters with β-ketoacids

J Org Chem. 2015 Apr 17;80(8):3766-76. doi: 10.1021/jo502741z. Epub 2015 Mar 26.

Authors

Ai-Jia Wei¹, Jing Nie¹, Yan Zheng¹, Jun-An Ma¹

Affiliation

¹ Department of Chemistry, Key Laboratory of Systems Bioengineering (The Ministry of Education), Tianjin University, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, P. R. of China.

PMID: 25785671
DOI: 10.1021/jo502741z

Abstract

A novel Ni-catalyzed decarboxylative aldol reaction of β,γ-unsaturated α-ketoesters with β-ketoacids is reported. The reaction proceeds smoothly with high chemo-, regio-, and enantioselectivity. This protocol provides a convenient approach to access enantioenriched chiral tertiary alcohols.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Coordination Complexes / chemistry*
Keto Acids / chemistry*
Nickel / chemistry*
Stereoisomerism

Substances

Coordination Complexes
Keto Acids
Nickel