Aim: To study remodeling of heart and its influence on intracellular metabolism of neutrophils in obese men.
Materials and methods: 85 men aged 30-63 years free from coronary heart disease underwent ECG examination with the evaluation of diastolic properties and diagnostics of left ventricle remodeling with special reference to oxygen-dependent metabolism and antioxidant protection of neutrophils.
Results and discussion: Increased degree of obesity in men leads to enhanced frequency of diastolic dysfunction and left ventricular myocardium remodeling accompanied by a rise in myeloperoxidase activity in neutrophils. The latter was especially high in patients with concentric hypertrophy of left ventricular myocardium.
Conclusion: Increased degree of heart remodeling with enhanced severity of obesity in men is accompanied by activation of oxygen-dependent metabolism in neutrophils.