Disease associated cellular machinery in anaphylaxis - And the de novo paradigm shift

Peter Natesan Pushparaj; Mahmood Rasool; Muhammad Imran Naseer; Laila Abdullah Damiati; Narasimhan Kothandaraman; Kalamegam Gauthaman; Sami Bhalas; Jayapal Manikandan

doi:10.6026/97320630011043

Disease associated cellular machinery in anaphylaxis - And the de novo paradigm shift

Bioinformation. 2015 Jan 30;11(1):43-6. doi: 10.6026/97320630011043. eCollection 2015.

Authors

Peter Natesan Pushparaj¹, Mahmood Rasool¹, Muhammad Imran Naseer¹, Laila Abdullah Damiati², Narasimhan Kothandaraman¹, Kalamegam Gauthaman¹, Sami Bhalas³, Jayapal Manikandan⁴

Affiliations

¹ Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia.
² King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia.
³ Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia.
⁴ Faculty of Life and Physical Sciences, The University of Western Australia (M011), 35 Stirling Highway, Crawley, WA 6009, Australia.

Abstract

Anaphylaxis is a sudden immune reaction against an allergen that can potentially lead to Anaphylactic Shock (AS). This immune reaction is characterized by an increase in Immunoglobulin-E (IgE) type of antibodies that bind with FcεRI receptors on mast cells to release inflammatory mediators. Various intracellular signaling molecules downstream of IgE/ FcεRI axis play a potential role in cytokine, chemokine and eicosanoid secretion as well as degranulation of immune cells causing vasodilation, vascular permeability, and reduction of intravascular volume leading to cardiovascular collapse. Here, we discuss the cellular machinery of anaphylaxis and the de novo paradigm shift in the cellular aspects of AS.

Keywords: Anaphylactic shock; Anaphylaxis; Chemokines; Cytokines; Immunoglobulin E; Mast cells; Paradigm shift.