A novel method for delineation of oral mucosa for radiotherapy dose-response studies

Jamie A Dean; Liam C Welsh; Sarah L Gulliford; Kevin J Harrington; Christopher M Nutting

doi:10.1016/j.radonc.2015.02.020

A novel method for delineation of oral mucosa for radiotherapy dose-response studies

Radiother Oncol. 2015 Apr;115(1):63-6. doi: 10.1016/j.radonc.2015.02.020. Epub 2015 Mar 13.

Authors

Jamie A Dean¹, Liam C Welsh², Sarah L Gulliford³, Kevin J Harrington², Christopher M Nutting²

Affiliations

¹ Joint Department of Physics at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK. Electronic address: jamie.dean@icr.ac.uk.
² Head and Neck Unit, The Royal Marsden NHS Foundation Trust, London, UK.
³ Joint Department of Physics at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK.

Abstract

There is currently no standard method for delineating the oral mucosa and most attempts are oversimplified. A new method to obtain anatomically accurate contours of the oral mucosa surfaces was developed and applied to 11 patients. This is expected to represent an opportunity for improved toxicity modelling of oral mucositis.

Keywords: Contouring; Delineation; Dose–response; Oral mucosa; Oral mucositis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Mouth Mucosa / anatomy & histology*
Mouth Mucosa / radiation effects*
Radiotherapy Dosage*
Radiotherapy Planning, Computer-Assisted / adverse effects
Radiotherapy Planning, Computer-Assisted / methods*
Stomatitis / etiology*

Abstract

Publication types

MeSH terms

Grants and funding