Increased risk of cutaneous melanoma associated with p53 Arg72Pro polymorphism

PLoS One. 2015 Mar 16;10(3):e0118112. doi: 10.1371/journal.pone.0118112. eCollection 2015.

Abstract

Objective: The objective of this study was to test the hypothesis that p53 Arg72Pro polymorphism may contribute to an increased risk of cutaneous melanoma (CM).

Methods: By searching the databases of PubMed, EMBASE, and Web of Science, a total of 8 eligible case-control studies with 1,957 CM cases and 2,887 controls were included in this meta-analysis. Stata software was used to analyze all the statistical data.

Results: The pooled data by a fixed-effects model suggested an increased risk of CM associated with p53 Arg72Pro polymorphism under the genetic model of Arg/Pro vs. Pro/Pro without heterogeneity (ORArg/Pro vs. Pro/Pro = 1.76, 95% CI = 1.55-1.99, Pheterogeneity = 0.075). A similar trend was seen in subgroups of hospital-based studies and population-based studies.

Conclusion: Our meta-analysis based on all studies shows that the p53 Arg72Pro polymorphism may increase individual susceptibility to CM, particularly in Caucasians and could serve as a biomarker to predict the population at high risk of CM.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor / genetics
  • Case-Control Studies
  • Databases, Genetic
  • Genes, p53*
  • Genetic Predisposition to Disease
  • Humans
  • Melanoma / genetics*
  • Melanoma, Cutaneous Malignant
  • Polymorphism, Single Nucleotide
  • Risk Factors
  • Skin Neoplasms
  • Tumor Suppressor Protein p53 / genetics*

Substances

  • Biomarkers, Tumor
  • TP53 protein, human
  • Tumor Suppressor Protein p53

Grants and funding

This work was supported by grant number 81272364 from the National Natural Science Foundation of China (to HJL). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.