Extracellular vesicles, tissue factor, cancer and thrombosis - discussion themes of the ISEV 2014 Educational Day

Chris Gardiner; Paul Harrison; Mattias Belting; Anita Böing; Elena Campello; Bob S Carter; Mary E Collier; Frank Coumans; Camille Ettelaie; Nick van Es; Fred H Hochberg; Nigel Mackman; Robert C Rennert; Johannes Thaler; Janusz Rak; Rienk Nieuwland

doi:10.3402/jev.v4.26901

Extracellular vesicles, tissue factor, cancer and thrombosis - discussion themes of the ISEV 2014 Educational Day

J Extracell Vesicles. 2015 Mar 13:4:26901. doi: 10.3402/jev.v4.26901. eCollection 2015.

Authors

Chris Gardiner¹, Paul Harrison², Mattias Belting³, Anita Böing⁴, Elena Campello⁵, Bob S Carter⁶, Mary E Collier⁷, Frank Coumans^{4

8}, Camille Ettelaie⁹, Nick van Es¹⁰, Fred H Hochberg^{6

11}, Nigel Mackman¹², Robert C Rennert⁶, Johannes Thaler¹³, Janusz Rak¹⁴, Rienk Nieuwland⁴

Affiliations

¹ Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Level 3 Women's Centre, John Radcliffe Hospital, Oxford, UK; chris.gardiner@obs-gyn.ox.ac.uk.
² School of Immunity and Infection, University of Birmingham Medical School, Birmingham, UK.
³ Department of Oncology and Pathology, Clinical Sciences, Skåne University Hospital, Lund, Sweden.
⁴ Department of Clinical Chemistry, Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands.
⁵ Department of Cardiologic, Thoracic and Vascular Sciences, University of Padua Medical School, Padua, Italy.
⁶ Division of Neurosurgery, University of California San Diego, La Jolla, CA, USA.
⁷ Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, UK.
⁸ Department of Biomedical Engineering and Physics, Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands.
⁹ School of Biological, Biomedical and Environmental Sciences, The University of Hull, Hull, UK.
¹⁰ Department of Vascular Medicine, Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands.
¹¹ Department of Neurology and Program in Neuroscience, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
¹² Thrombosis and Hemostasis Program, Department of Medicine, UNC McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
¹³ Clinical Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
¹⁴ Department of Pediatrics, McGill University, Montreal Children's Hospital Research Institute MUHC, Montreal, QC, Canada.

Abstract

Although the association between cancer and venous thromboembolism (VTE) has long been known, the mechanisms are poorly understood. Circulating tissue factor-bearing extracellular vesicles have been proposed as a possible explanation for the increased risk of VTE observed in some types of cancer. The International Society for Extracellular Vesicles (ISEV) and International Society on Thrombosis and Haemostasis (ISTH) held a joint Educational Day in April 2014 to discuss the latest developments in this field. This review discusses the themes of that event and the ISEV 2014 meeting that followed.

Keywords: cancer; extracellular vesicles; thrombosis; tissue factor.

Abstract

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