Differentiation of enantiomers by 2D NMR spectroscopy at 1 T using residual dipolar couplings

Martin R M Koos; Ernesto Danieli; Federico Casanova; Bernhard Blümich; Burkhard Luy

doi:10.1002/mrc.4222

Differentiation of enantiomers by 2D NMR spectroscopy at 1 T using residual dipolar couplings

Magn Reson Chem. 2016 Jun;54(6):527-30. doi: 10.1002/mrc.4222. Epub 2015 Mar 13.

Authors

Martin R M Koos¹, Ernesto Danieli², Federico Casanova³, Bernhard Blümich², Burkhard Luy¹

Affiliations

¹ Institut für Organische Chemie (IOC) and Institut für Biologische Grenzflächen (IBG), Karlsruher Institut für Technologie (KIT), Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany.
² Institut für Technische und Makromolekulare Chemie (ITMC), Lehrstuhl für Makromolekulare Chemie, RWTH Aachen, Worringerweg 1, 52074, Aachen, Germany.
³ Magritek GmbH, Pauwelsstrasse 8, 52068, Aachen, Germany.

PMID: 25773020
DOI: 10.1002/mrc.4222

Abstract

Differentiating enantiomers using 2D bench-top NMR spectroscopy. Spectrometers working with permanent magnets at 1 T field strength allow the acquisition of 2D data sets. In conjunction with previously reported chiral alignment media, this setup allows the measurement of enantiomeric excess via residual dipolar couplings in stretched gelatine as a result of the reduced line width obtained by 2D J-resolved spectroscopy.

Keywords: RDC; chiral alignment media; differentiation of enantiomers; enantiomeric excess; low-field NMR.