Mechanism of the cytotoxic action of immunophototoxin 4D5scFV-miniSOG on HER2/neu-positive cancer cells

Dokl Biochem Biophys. 2015:460:16-9. doi: 10.1134/S1607672915010056. Epub 2015 Mar 13.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / drug therapy
  • Adenocarcinoma / metabolism
  • Adenocarcinoma / pathology
  • Antigens, Nuclear / metabolism*
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / pathology
  • Caspase 3 / metabolism
  • Cell Death / drug effects
  • Cell Death / physiology
  • Cell Death / radiation effects
  • Cell Line, Tumor
  • Flavoproteins / pharmacology*
  • Humans
  • Light
  • Nerve Tissue Proteins / metabolism*
  • Photochemotherapy / methods*
  • Photosensitizing Agents / pharmacology*
  • Receptor, ErbB-2 / metabolism*
  • Recombinant Fusion Proteins / pharmacology*
  • Single-Chain Antibodies / pharmacology*

Substances

  • 4D5scFv-miniSOG immunophototoxin
  • Antigens, Nuclear
  • Flavoproteins
  • Nerve Tissue Proteins
  • Photosensitizing Agents
  • Recombinant Fusion Proteins
  • Single-Chain Antibodies
  • neuronal nuclear antigen NeuN, human
  • ERBB2 protein, human
  • Receptor, ErbB-2
  • CASP3 protein, human
  • Caspase 3