IAPs and cell migration

Laurence Dubrez; Krishnaraj Rajalingam

doi:10.1016/j.semcdb.2015.02.015

IAPs and cell migration

Semin Cell Dev Biol. 2015 Mar:39:124-31. doi: 10.1016/j.semcdb.2015.02.015. Epub 2015 Mar 10.

Authors

Laurence Dubrez¹, Krishnaraj Rajalingam²

Affiliations

¹ Institut National de la Santé et de la Recherche Médicale (Inserm) UMR866, Dijon F-21079, France; Université de Bourgogne, Dijon F-21079, France. Electronic address: ldubrez@u-bourgogne.fr.
² Molecular Signaling Unit, FZI, Institute for Immunology, JGU University Medical Center, Langenbeck Str. 1, 55131 Mainz, Germany; Institute for Biochemistry II, Goethe University Medical School, Frankfurt, Germany. Electronic address: Krishna@uni-mainz.de.

PMID: 25769935
DOI: 10.1016/j.semcdb.2015.02.015

Abstract

Inhibitors of apoptosis (IAPs) constitute a family of cell signaling regulators controlling several fundamental biological processes such as innate immunity, inflammation, cell death, cell proliferation, and cell differentiation. Increasing evidence from in vivo and in vitro studies indicate a function for IAPs in the modulation of invasive and migratory properties of cells. Here, we present and discuss the mechanisms whereby IAPs can control cell migration.

Keywords: IAPs; Invasion; Migration; RhoGTPases; Signaling; Ubiquitination.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Adhesion
Cell Movement*
Cytoskeleton / metabolism
Humans
Inhibitor of Apoptosis Proteins / metabolism*
Signal Transduction

Substances

Inhibitor of Apoptosis Proteins