RIG-I works double duty

Ying Kai Chan; Michaela U Gack

doi:10.1016/j.chom.2015.02.014

RIG-I works double duty

Cell Host Microbe. 2015 Mar 11;17(3):285-287. doi: 10.1016/j.chom.2015.02.014.

Authors

Ying Kai Chan¹, Michaela U Gack²

Affiliations

¹ Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
² Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address: michaela_gack@hms.harvard.edu.

Abstract

The pathogen sensor RIG-I recognizes viral RNA and signals to induce an antiviral response. In this issue of Cell Host & Microbe, Weber et al. (2015), along with recent work by Sato et al. (2015), demonstrate that RIG-I directly inhibits viral replication independent of antiviral signaling.

Publication types

Comment

MeSH terms

Animals
Female
Gene Products, pol / antagonists & inhibitors*
Hepatitis B virus / physiology*
Hepatitis B, Chronic / immunology*
Hepatocytes / physiology*
Humans
Liver / physiology*
Membrane Proteins / metabolism*
Nerve Tissue Proteins / metabolism*
RNA, Viral / immunology*

Substances

Gene Products, pol
Membrane Proteins
Nerve Tissue Proteins
RNA, Viral

Grants and funding

R21 AI097699/AI/NIAID NIH HHS/United States