Association of FPGS genetic polymorphisms with primary retroperitoneal liposarcoma

Sci Rep. 2015 Mar 13:5:9079. doi: 10.1038/srep09079.

Abstract

Primary retroperitoneal liposarcoma is generally regarded as a genetic disorder. We have retrospectively genotyped 8 single nucleotide polymorphisms (SNPs) in 6 candidate genes (MDM2, CDK4, CDC27, FPGS, IGFN1, and PRAMEF13) in 138 patients and 131 healthy control subjects to evaluate the effects of genetic factors on individual susceptibility to primary retroperitoneal liposarcoma in Chinese population. Three SNPs (rs2870820, rs1695147, rs3730536) of MDM2 showed significant differences in single-loci genotypes and allele frequencies between case and control groups (p < 0.05). The minor allele G of SNP rs10760502 in FPGS (folylpolyglutamate synthase) gene was significantly associated with increased risk for primary retroperitoneal liposarcoma, compared with major allele A. Our data suggest that FPGS variant in Chinese population may affect individual susceptibility to primary retroperitoneal liposarcoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alleles
  • Amino Acid Sequence
  • Case-Control Studies
  • Computational Biology
  • DNA Mutational Analysis
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Linkage Disequilibrium
  • Liposarcoma / genetics*
  • Liposarcoma / pathology
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Mutation
  • Peptide Synthases / chemistry
  • Peptide Synthases / genetics*
  • Polymorphism, Single Nucleotide*
  • Protein Structure, Secondary
  • Retroperitoneal Neoplasms / genetics*
  • Retroperitoneal Neoplasms / pathology
  • Risk Factors
  • Tumor Burden
  • Young Adult

Substances

  • Peptide Synthases
  • folylpolyglutamate synthetase

Supplementary concepts

  • Retroperitoneal liposarcoma