Abstract
Two new phenolic glucosides, 1-O-benzyl-6-O-E-caffeoyl-β-d-glucopyranoside and 1-O-(7S,8R)-guaiacylglycerol-(6-O-E-caffeoyl)-β-d-glucopyranoside, were isolated from the aerial parts of Lagerstroemia speciosa, along with ten known compounds. The structures of the isolated compounds were determined based on 1D- and 2D-NMR, Q-TOF MS and optical rotation spectroscopic data. All of the compounds showed moderate inhibitory activities against nitric oxide production in lipopolysaccharide-treated RAW264.7 cells, with IC50 values of 69.5-83.3 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / chemistry*
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Antioxidants / pharmacology
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Cell Line
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Drugs, Chinese Herbal / chemistry
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Glucosides / chemistry*
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Glucosides / pharmacology
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Lagerstroemia / chemistry*
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Nitric Oxide / metabolism
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Phenols / chemistry*
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Phenols / pharmacology
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Plant Components, Aerial / chemistry
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Plant Extracts / chemistry*
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Plant Extracts / pharmacology
Substances
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1-O-(7S,8R)-guaiacylglycerol-(6-O-E-caffeoyl)-beta-D-glucopyranoside
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1-O-benzyl-6-O-E-caffeoyl-beta-D-glucopyranoside
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Antioxidants
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Drugs, Chinese Herbal
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Glucosides
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Phenols
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Plant Extracts
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Nitric Oxide