Two new phenolic glucosides from Lagerstroemia speciosa

Molecules. 2015 Mar 10;20(3):4483-91. doi: 10.3390/molecules20034483.

Abstract

Two new phenolic glucosides, 1-O-benzyl-6-O-E-caffeoyl-β-d-glucopyranoside and 1-O-(7S,8R)-guaiacylglycerol-(6-O-E-caffeoyl)-β-d-glucopyranoside, were isolated from the aerial parts of Lagerstroemia speciosa, along with ten known compounds. The structures of the isolated compounds were determined based on 1D- and 2D-NMR, Q-TOF MS and optical rotation spectroscopic data. All of the compounds showed moderate inhibitory activities against nitric oxide production in lipopolysaccharide-treated RAW264.7 cells, with IC50 values of 69.5-83.3 μM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / chemistry*
  • Antioxidants / pharmacology
  • Cell Line
  • Drugs, Chinese Herbal / chemistry
  • Glucosides / chemistry*
  • Glucosides / pharmacology
  • Lagerstroemia / chemistry*
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Structure
  • Nitric Oxide / metabolism
  • Phenols / chemistry*
  • Phenols / pharmacology
  • Plant Components, Aerial / chemistry
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology

Substances

  • 1-O-(7S,8R)-guaiacylglycerol-(6-O-E-caffeoyl)-beta-D-glucopyranoside
  • 1-O-benzyl-6-O-E-caffeoyl-beta-D-glucopyranoside
  • Antioxidants
  • Drugs, Chinese Herbal
  • Glucosides
  • Phenols
  • Plant Extracts
  • Nitric Oxide