A new cytotoxic benzophenanthridine isoquinoline alkaloid from the fruits of Macleaya cordata

J Asian Nat Prod Res. 2015;17(8):856-60. doi: 10.1080/10286020.2015.1016000. Epub 2015 Mar 11.

Abstract

A new cytotoxic benzophenanthridine isoquinoline alkaloid, named cordatine (1), together with one known alkaloid 8-methoxydihydrochelerythrine (2), was isolated from the fruits of Macleaya cordata. The structure of the new compound was elucidated by spectroscopic methods including 1D and 2D NMR, HR-ESI-MS. Both compounds indicated significant cytotoxicity against MCF-7 and SF-268 cell lines.

Keywords: Macleaya cordata; benzophenanthridine alkaloid; cordatine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology*
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Benzophenanthridines / chemistry
  • Benzophenanthridines / isolation & purification*
  • Benzophenanthridines / pharmacology*
  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology*
  • Fruit / chemistry*
  • Humans
  • Isoquinolines
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Papaveraceae / chemistry*

Substances

  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Benzophenanthridines
  • Drugs, Chinese Herbal
  • Isoquinolines
  • cordatine
  • isoquinoline