Abstract
A new cytotoxic benzophenanthridine isoquinoline alkaloid, named cordatine (1), together with one known alkaloid 8-methoxydihydrochelerythrine (2), was isolated from the fruits of Macleaya cordata. The structure of the new compound was elucidated by spectroscopic methods including 1D and 2D NMR, HR-ESI-MS. Both compounds indicated significant cytotoxicity against MCF-7 and SF-268 cell lines.
Keywords:
Macleaya cordata; benzophenanthridine alkaloid; cordatine.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Benzophenanthridines / chemistry
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Benzophenanthridines / isolation & purification*
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Benzophenanthridines / pharmacology*
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Fruit / chemistry*
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Humans
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Isoquinolines
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Papaveraceae / chemistry*
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Benzophenanthridines
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Drugs, Chinese Herbal
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Isoquinolines
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cordatine
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isoquinoline