Abstract
Two heterodimers comprising anthraquinone and methylbenzoisocoumarin moieties (1 and 2) were isolated, together with emodin and physcion from the tubers of Pyrenacantha kaurabassana. The structures of 1 and 2 were established by NMR spectroscopy, including the analysis of a 2D INADEQUATE spectrum. On the basis of the data obtained, the structures that were previously proposed in the literature for these compounds were revised. Compounds 1 and 2 showed antibacterial activity against three different strains of Staphylococcus aureus. Compound 2 also showed bactericidal activity against Helicobacter pylori.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anthraquinones / chemistry
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Anthraquinones / isolation & purification*
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Anthraquinones / pharmacology*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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Coumarins / chemistry
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Coumarins / isolation & purification*
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Coumarins / pharmacology*
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Emodin / analogs & derivatives
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Emodin / chemistry
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Emodin / isolation & purification
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Helicobacter pylori / drug effects
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Magnoliopsida / chemistry*
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Microbial Sensitivity Tests
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Molecular Structure
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Mozambique
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Nuclear Magnetic Resonance, Biomolecular
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Plant Tubers / chemistry
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Polyketides / chemistry
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Polyketides / isolation & purification*
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Polyketides / pharmacology*
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Staphylococcus aureus / drug effects
Substances
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Anthraquinones
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Anti-Bacterial Agents
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Coumarins
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Polyketides
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physcione
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Emodin