Schizophyllum commune-induced allergic fungal rhinosinusitis and sinobronchial mycosis

Toshiaki Tsukatani; Haruhiko Ogawa; Kazushi Anzawa; Eiji Kobayashi; Hiroki Hasegawa; Koichi Makimura; Tomokazu Yoshizaki; Norishi Ueda

doi:10.1016/j.mmcr.2015.02.004

Schizophyllum commune-induced allergic fungal rhinosinusitis and sinobronchial mycosis

Med Mycol Case Rep. 2015 Feb 24:8:10-3. doi: 10.1016/j.mmcr.2015.02.004. eCollection 2015 Jun.

Authors

Toshiaki Tsukatani¹, Haruhiko Ogawa², Kazushi Anzawa³, Eiji Kobayashi¹, Hiroki Hasegawa¹, Koichi Makimura⁴, Tomokazu Yoshizaki⁵, Norishi Ueda⁶

Affiliations

¹ Department of Otorhinolaryngology, Public Central Hospital of Matto Ishikawa, Hakusan, Ishikawa 924-8588, Japan.
² Division of Pulmonary Medicine, Ishikawa-ken Saiseikai Kanazawa Hospital, Kanazawa, Ishikawa, Japan.
³ Division of Dermatomycology (Novartis Pharma), Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
⁴ Laboratory of Space and Environmental Medicine, Teikyo University, Hachioji, Tokyo, Japan.
⁵ Department of Otorhinolaryngology, Head and Neck Surgery, Kanazawa University, Kanazawa, Ishikawa, Japan.
⁶ Department of Pediatrics, Public Central Hospital of Matto Ishikawa, Hakusan, Ishikawa, Japan.

Abstract

We present 32- and 38-year-old males with Schizophyllum commune-induced allergic fungal rhinosinusitis (AFRS). S. commune-induced AFRS was diagnosed by clinical and radiographic findings, positive specific IgE antibodies against S. commune as measured by the ImmunoCAP system, and sequencing analysis of the fungus. Our two cases with S. commune-induced AFRS for the first time showed evidence for type 1 hypersensitivity to S. commune as determined by using specific IgE antibodies against S. commune, and the fungus was identified by sequence analysis.

Keywords: Allergic fungal rhinosinusitis; Bronchial asthma; Schizophyllum commune; Sinobronchial allergic mycosis.