Magnetic property, DFT calculation, and biological activity of bis[(μ(2)-chloro)chloro(1,10-phenanthroline)copper(II)] complex

Mohammad Mroueh; Costantine Daher; Essa Hariri; Sally Demirdjian; Samih Isber; Eun Sang Choi; Babak Mirtamizdoust; Hassan H Hammud

doi:10.1016/j.cbi.2015.02.023

Magnetic property, DFT calculation, and biological activity of bis[(μ(2)-chloro)chloro(1,10-phenanthroline)copper(II)] complex

Chem Biol Interact. 2015 Apr 25:231:53-60. doi: 10.1016/j.cbi.2015.02.023. Epub 2015 Mar 7.

Authors

Mohammad Mroueh¹, Costantine Daher², Essa Hariri², Sally Demirdjian², Samih Isber³, Eun Sang Choi⁴, Babak Mirtamizdoust⁵, Hassan H Hammud⁶

Affiliations

¹ School of Pharmacy, Lebanese American University, Byblos, Lebanon.
² School of Arts and Sciences, Lebanese American University, Byblos, Lebanon.
³ Department of Physics, American University of Beirut, 11-0236 Beirut, Lebanon.
⁴ National High Magnetic Field Lab, Florida, Tallahassee, FL 32310-3706, USA.
⁵ Department of Chemistry, Faculty of Science, University of Qom, PO Box 37185-359, Qom, Iran.
⁶ Chemistry Department, Faculty of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia. Electronic address: hhammoud@kfu.edu.sa.

PMID: 25753321
DOI: 10.1016/j.cbi.2015.02.023

Abstract

The dinuclear complex bis[(μ(2)-chloro)chloro(1,10-phenanthroline)copper(II)] (1) was synthesized, and characterized by X-ray, FTIR and thermal analysis. The fitting of magnetic susceptibility and magnetization curve of (1) indicates the occurrence of weak antiferromagnetic exchange interaction between copper(II) ions. The electronic structure has been also determined by density functional theory (DFT) method. Complex (1) displayed potent anticancer activity against B16 (Melanoma), MDA-MB-32 (Breast Adenocarcinoma), A549 (Lung Adenocarcinoma), HT-29 (Colon Adenocarcinoma) and SF (Astrocytoma) cell lines with an average IC50 value of 0.726 μg/ml compared to 4.88 μg/ml for cisplatin. Complex (1) has a better therapeutic index and toxicological profile than cisplatin, and has demonstrated a potential chemotherapeutic property.

Keywords: Anticancer; Copper(II) phenanthroline; DFT; In vitro cytotoxicity; Magnetism; Thermal.

MeSH terms

Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology
Cell Line, Tumor
Coordination Complexes / chemistry*
Coordination Complexes / pharmacology
Copper / chemistry*
Copper / pharmacology
Crystallography, X-Ray
Halogenation
Humans
Magnetic Phenomena
Models, Molecular
Neoplasms / drug therapy
Phenanthrolines / chemistry*
Phenanthrolines / pharmacology

Substances

Antineoplastic Agents
Coordination Complexes
Phenanthrolines
Copper
1,10-phenanthroline