Automated radiosynthesis of [(18)F]ciprofloxacin

Appl Radiat Isot. 2015 May:99:133-7. doi: 10.1016/j.apradiso.2015.02.024. Epub 2015 Feb 27.

Abstract

We transferred the previously published manual synthesis of [(18)F]ciprofloxacin (decay-corrected RCY: 5.5±1.0%) to an automated synthesis module (TRACERlab(TM) FXFDG, GE Healthcare) and observed a strong decrease in RCY (0.4±0.4%). When replacing the standard 15-mL glassy carbon reactor of the synthesis module with a 3-mL V-shaped borosilicate glass reactor a considerable improvement in RCY was observed. [(18)F]Ciprofloxacin was obtained in a RCY of 2.7±1.4% (n=23) with a specific activity at EOS of 1.4±0.5GBq/µmol in a synthesis time of 160min.

Keywords: (18)F/(19)F exchange; Automated synthesis; Radiochemical yield; Reactor type; TRACERlab(TM) FX(FDG); [(18)F]ciprofloxacin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ciprofloxacin / chemistry*
  • Ciprofloxacin / isolation & purification
  • Equipment Design
  • Equipment Failure Analysis
  • Fluorine Radioisotopes / chemistry*
  • Fluorine Radioisotopes / isolation & purification
  • Isotope Labeling / instrumentation*
  • Isotope Labeling / methods
  • Radiopharmaceuticals / chemical synthesis*
  • Radiopharmaceuticals / isolation & purification
  • Robotics / instrumentation*
  • Robotics / methods

Substances

  • Fluorine Radioisotopes
  • Radiopharmaceuticals
  • Ciprofloxacin