The clinical applicability of CAD/CAM-fabricated zirconia copings is tested using working models made from four different highstrength Type IV gypsum materials. Each of the four materials was used to fabricate 15 zirconia copings. Precision of fit was measured with a digital electron microscope using the silicone replica technique. The mean and standard deviation of each reference point were analyzed using the one-way analysis of the variance (ANOVA) and Tukey's honest significant difference (HSD) tests (α=0.05). The overall marginal and internal fits of the zirconia copings were as follows: GS (GS: Grey Stone) group: 91.43 μm, LS (LS: Light green Stone) Group: 87.89 μm, RS (RS: Red Stone) Group: 88.75 μm, BS (BS: Beige Stone) Group: 82.78 μm. There were no significant differences between the mean adaptations of the gypsum varieties (p>0.05). This confirmed that the type of gypsum material used does not determine the precision of fit of a prosthesis.