Serum soluble RAGE levels and carotid atherosclerosis: the Northern Manhattan Study (NOMAS)

Barry I Hudson; Hannah Gardener; Wen Liu-Mares; Chuanhui Dong; Ken Cheung; Mitchell S V Elkind; Clinton B Wright; Ralph L Sacco; Tatjana Rundek

doi:10.1016/j.atherosclerosis.2015.02.015

Serum soluble RAGE levels and carotid atherosclerosis: the Northern Manhattan Study (NOMAS)

Atherosclerosis. 2015 May;240(1):17-20. doi: 10.1016/j.atherosclerosis.2015.02.015. Epub 2015 Feb 24.

Authors

Barry I Hudson¹, Hannah Gardener², Wen Liu-Mares³, Chuanhui Dong², Ken Cheung⁴, Mitchell S V Elkind⁵, Clinton B Wright⁶, Ralph L Sacco⁷, Tatjana Rundek⁸

Affiliations

¹ Division of Endocrinology, Diabetes & Metabolism, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
² Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
³ Department of Epidemiology and Public Health, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
⁴ Department of Biostatistics, Mailman Public School of Health, Columbia University, New York, NY, USA.
⁵ Stroke Division, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Mailman Public School of Health, Columbia University, New York, NY, USA.
⁶ Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA; Department of Epidemiology and Public Health, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA; Evelyn F. McKnight Brain Institute, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA; Neuroscience Program, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
⁷ Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA; Department of Epidemiology and Public Health, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA; Evelyn F. McKnight Brain Institute, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
⁸ Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA; Department of Epidemiology and Public Health, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.

PMID: 25744702
PMCID: PMC4880353
DOI: 10.1016/j.atherosclerosis.2015.02.015

Abstract

Background: Recent cohort studies suggested that serum levels of soluble Receptor for Advanced Glycation End-products (sRAGE) are associated with the risk of cardiovascular disease. We hypothesized that sRAGE levels are associated with subclinical atherosclerosis in a racially and ethnically diverse population.

Methods and results: 828 stroke-free participants from the Northern Manhattan Study (mean age 71.1±8.7yrs; 64% Hispanic, 19% black, and 17% white) underwent high-resolution carotid B-mode ultrasound to measure carotid plaque (present in 62% of subjects) and intima-media thickness (IMT) (mean Total=0.96±0.10 mm). Serum sRAGE was measured by ELISA and associations tested between sRAGE with IMT and plaque presence. Soluble RAGE levels were not associated with plaque presence or IMT after adjusting for sociodemographic, vascular risk factors and medication use. Stratification by race-ethnicity did not reveal any associations with carotid IMT or plaque.

Conclusion: In the present study, sRAGE levels were not associated with carotid atherosclerosis.

Keywords: Atherosclerosis; Biological marker; Carotid ultrasound; Hispanics; IMT; Plaque; RAGE (receptor for advanced glycation end products).

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers / blood
Black or African American
Carotid Artery Diseases / blood*
Carotid Artery Diseases / diagnosis
Carotid Artery Diseases / ethnology
Carotid Intima-Media Thickness
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Female
Hispanic or Latino
Humans
Male
New York City / epidemiology
Plaque, Atherosclerotic
Receptor for Advanced Glycation End Products / blood*
Risk Factors
White People

Substances

AGER protein, human
Biomarkers
Receptor for Advanced Glycation End Products

Abstract

Publication types

MeSH terms

Substances

Grants and funding