Sensory TRP channels: the key transducers of nociception and pain

Prog Mol Biol Transl Sci. 2015:131:73-118. doi: 10.1016/bs.pmbts.2015.01.002. Epub 2015 Feb 12.

Abstract

Peripheral detection of nociceptive and painful stimuli by sensory neurons involves a complex repertoire of molecular detectors and/or transducers on distinct subsets of nerve fibers. The majority of such molecular detectors/transducers belong to the transient receptor potential (TRP) family of cation channels, which comprise both specific receptors for distinct nociceptive stimuli, as well as for multiple stimuli. This chapter discusses the classification, distribution, and functional properties of individual TRP channel types that have been implicated in various nociceptive and/or painful conditions.

Keywords: Nociception; Pain; TRP channel; TRPA1; TRPM3; TRPM8; TRPV1; TRPV2; TRPV3; TRPV4.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Models, Biological
  • Nociception*
  • Pain / metabolism*
  • Sense Organs / metabolism*
  • Signal Transduction
  • Transient Receptor Potential Channels / metabolism*

Substances

  • Transient Receptor Potential Channels