Abstract
Filoviruses are responsible for highly lethal infections. Those viruses are found in intertropical areas of Africa and Asia where they circulate in their supposed natural reservoir, fruit bats. During filovirus outbreaks and depending on the strains, various modifications in hemostasis have been observed in patients. The disseminated intravascular coagulation identified in these infections is multicausal and involves both viral factors and abnormal physiological responses. In this review we will describe the mechanisms responsible for these disturbances and we will highlight some aspects of the basis of filovirus high pathogenicity.
© 2015 médecine/sciences – Inserm.
MeSH terms
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Adrenal Cortex / pathology
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Animals
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Chiroptera / virology
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Communicable Diseases, Emerging / blood
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Communicable Diseases, Emerging / complications
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Cytokines / metabolism
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Disease Reservoirs
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Disseminated Intravascular Coagulation / etiology*
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Endothelial Cells / pathology
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Filoviridae / physiology
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Filoviridae Infections / blood*
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Filoviridae Infections / epidemiology
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Filoviridae Infections / pathology
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Filoviridae Infections / veterinary
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Filoviridae Infections / virology
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Haplorhini
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Hepatocytes / pathology
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Host-Pathogen Interactions
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Humans
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Necrosis
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Recombinant Proteins / pharmacology
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Recombinant Proteins / therapeutic use
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Thromboplastin / antagonists & inhibitors
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Thromboplastin / physiology
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Viral Load
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Viral Proteins / physiology
Substances
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Cytokines
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Recombinant Proteins
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Viral Proteins
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Thromboplastin