Treatment of mediastinitis due to methicillin-resistant Staphylococcus aureus in a renal dysfunction patient undergoing adjustments to the linezolid dose

Intern Med. 2015;54(2):235-9. doi: 10.2169/internalmedicine.54.2292. Epub 2015 Jan 15.

Abstract

This study is the first case report of the treatment of methicillin-resistant Staphylococcus aureus (MRSA) mediastinitis using therapeutic drug monitoring of the serum and wound exudate concentrations of linezolid in a renal dysfunction patient. In the present study, the serum trough concentration of linezolid was maintained between 2 and 7 μg/mL. Therapeutic drug monitoring dosage adjustments may be especially useful in patients with renal dysfunction and severe MRSA infection.

Publication types

  • Case Reports

MeSH terms

  • Acetamides / administration & dosage
  • Acetamides / adverse effects
  • Acetamides / therapeutic use*
  • Aged
  • Cardiac Surgical Procedures / adverse effects
  • Humans
  • Linezolid
  • Male
  • Mediastinitis / drug therapy*
  • Mediastinitis / epidemiology
  • Methicillin-Resistant Staphylococcus aureus*
  • Oxazolidinones / administration & dosage
  • Oxazolidinones / adverse effects
  • Oxazolidinones / therapeutic use*
  • Postoperative Complications / microbiology*
  • Renal Insufficiency / epidemiology
  • Staphylococcal Infections / drug therapy
  • Thrombocytopenia / chemically induced*

Substances

  • Acetamides
  • Oxazolidinones
  • Linezolid