Strategically designed biomodel: engineering C3-C4 cleavage of D-fructose

Org Biomol Chem. 2015 Apr 14;13(14):4210-20. doi: 10.1039/c4ob02666g. Epub 2015 Mar 5.

Abstract

Amongst a library of aldolase inspired, rationally designed compounds, the acridine derivative carrying a (S)-Tyr-Gly-(S)-Lys tripeptide selectively effected C3-C4 scissoring of D-fructose and produced D-glyceraldehyde and dihydroxyacetone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acridines / chemistry
  • Dihydroxyacetone / chemistry
  • Drug Design*
  • Fructose / chemistry*
  • Glyceraldehyde / chemistry

Substances

  • Acridines
  • Fructose
  • Glyceraldehyde
  • Dihydroxyacetone