An approach to fertility preservation in prepubertal and postpubertal females: a critical review of current literature

Pediatr Blood Cancer. 2015 Jun;62(6):935-9. doi: 10.1002/pbc.25440. Epub 2015 Mar 4.

Abstract

Advancements in childhood cancer treatment have led to increasing survivorship, creating a greater emphasis on long-term management of patients, including quality of life and side effects from therapy; foremost of which is preserving fertility. The American Society of Clinical Oncology (ASCO) recently revised their guidelines and recommend fertility preservation options be discussed at the earliest possible opportunity for newly diagnosed patients, including methods available for children that remain investigational. Herein, we discuss the current barriers to and the impact of these guidelines for pediatric oncologists caring for young female patients, and provide some suggestions on how to approach this complicated topic.

Keywords: fertility preservation; infertility; pediatric cancer survivor; pediatric oncology; prepubertal females.

Publication types

  • Review

MeSH terms

  • Cryopreservation
  • Female
  • Fertility Preservation*
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Neoplasms / physiopathology
  • Neoplasms / therapy*
  • Ovary / physiopathology
  • Puberty