Seroincidence of Influenza Among HIV-infected and HIV-uninfected Men During the 2009 H1N1 Influenza Pandemic, Bangkok, Thailand

Shikha Garg; Sonja J Olsen; Stefan Fernandez; Charung Muangchana; Kamonthip Rungrojcharoenkit; Prabda Prapasiri; Jacqueline M Katz; Marcel E Curlin; Robert V Gibbons; Timothy H Holtz; Anupong Chitwarakorn; Fatimah S Dawood

doi:10.1093/ofid/ofu082

Seroincidence of Influenza Among HIV-infected and HIV-uninfected Men During the 2009 H1N1 Influenza Pandemic, Bangkok, Thailand

Open Forum Infect Dis. 2014 Oct 10;1(3):ofu082. doi: 10.1093/ofid/ofu082. eCollection 2014 Dec.

Affiliations

¹ Division of HIV/AIDS Prevention.
² Influenza Division , Centers for Disease Control and Prevention , Atlanta, Georgia ; Thailand MoPH-U.S. CDC Collaboration , Nonthaburi.
³ Armed Forces Research Institute of Medical Sciences , Bangkok.
⁴ National Vaccine Institute , Nonthaburi.
⁵ Thailand MoPH-U.S. CDC Collaboration , Nonthaburi.
⁶ Influenza Division , Centers for Disease Control and Prevention , Atlanta, Georgia.
⁷ Division of HIV/AIDS Prevention ; Thailand MoPH-U.S. CDC Collaboration , Nonthaburi.
⁸ Department of Disease Control , Ministry of Public Health , Thailand.

Abstract

Among 368 Thai men who have sex with men with paired serum samples collected before and during the 2009 H1N1 influenza pandemic, we determined influenza A (H1N1)pdm09 seroconversion rates (≥4-fold rise in antibody titers by hemagglutination inhibition or microneutralization assays). Overall, 66 of 232 (28%) participants seroconverted after the first year of A(H1N1)pdm09 activity, and 83 of 234 (35%) participants seroconverted after the second year. Influenza A(H1N1)pdm09 seroconversion did not differ between human immunodeficiency virus (HIV)-infected (55 of 2157 [35%]) and HIV-uninfected (71 of 2211 [34%]) participants (P = .78). Influenza A(H1N1)pdm09 seroconversion occurred in approximately one third of our Thai study population and was similar among HIV-infected and HIV-uninfected participants.

Keywords: A(H1N1)pdm09; HIV; Thailand; influenza; pandemic; serology.