Malaria is still an important health problem worldwide, particularly in Sub-Saharan Africa. In Turkey, the most common type of malaria is Plasmodium vivax, and endemic regions are South-Eastern Anatolia and Çukurova. Due to globalization and tourism, travel-associated infection due to P. falciparum is also seen more frequently in Turkey. P. falciparum malaria can be highly fatal despite optimal antimalarial treatment. We present a case of falciparum malaria in a Turkish radiologist who went to Africa for occupational reasons and come back with malaria accompanied by uveitis, hyperglycemia, and purpuric rash.