Silencing sounds off

Elife. 2015 Mar 2:4:e06717. doi: 10.7554/eLife.06717.

Authors

Yu-Fan Chen¹, Marc R Gartenberg²

Affiliations

¹ Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, United States.
² Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, United States and The Cancer Institute of New Jersey, New Brunswick, United States marc.gartenberg@rutgers.edu.

Abstract

Silent chromatin in budding yeast is propagated from one generation to the next, even though 'silenced' genes are occasionally expressed.

Keywords: S. cerevisiae; Sir2; Sir3; Sir4; bistability; chromosomes; epigenetics; genes; histone H3.

MeSH terms

Chromatin / genetics*
Gene Silencing*
Genes, Fungal
Saccharomyces cerevisiae / genetics*

Substances

Chromatin

Grants and funding

R01 GM051402/GM/NIGMS NIH HHS/United States