The baroreflex as a long-term controller of arterial pressure

Physiology (Bethesda). 2015 Mar;30(2):148-58. doi: 10.1152/physiol.00035.2014.

Abstract

Because of resetting, a role for baroreflexes in long-term control of arterial pressure has been commonly dismissed in the past. However, in recent years, this perspective has changed. Novel approaches for determining chronic neurohormonal and cardiovascular responses to natural variations in baroreceptor activity and to electrical stimulation of the carotid baroreflex indicate incomplete resetting and sustained responses that lead to long-term alterations in sympathetic activity and arterial pressure.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Antihypertensive Agents / therapeutic use
  • Arterial Pressure* / drug effects
  • Baroreflex* / drug effects
  • Cardiovascular System / innervation*
  • Homeostasis
  • Humans
  • Hypertension / drug therapy
  • Hypertension / etiology
  • Hypertension / physiopathology
  • Mechanotransduction, Cellular*
  • Models, Cardiovascular
  • Obesity / complications
  • Obesity / physiopathology
  • Pressoreceptors / drug effects
  • Pressoreceptors / physiology*
  • Renin-Angiotensin System
  • Time Factors

Substances

  • Antihypertensive Agents