Serum anti-tissue transglutaminase antibodies detected during febrile illness may not be produced by the intestinal mucosa

J Pediatr. 2015 Mar;166(3):761-3. doi: 10.1016/j.jpeds.2014.12.005.

Abstract

Anti-transglutaminase antibodies are the diagnostic marker of celiac disease, and are considered to be synthesized only by intestinal B-lymphocytes. During an infectious disease, these antibodies are transiently detected in serum. We show that these infection-triggered antibodies may not originate in the intestinal mucosa and are not an indication of celiac disease.

Trial registration: ClinicalTrials.gov NCT00677495.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoantibodies / blood*
  • Celiac Disease / diagnosis
  • Celiac Disease / enzymology*
  • Celiac Disease / immunology
  • Child, Preschool
  • Diagnosis, Differential
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • GTP-Binding Proteins / blood
  • GTP-Binding Proteins / immunology*
  • Humans
  • Intestinal Mucosa / immunology*
  • Intestinal Mucosa / pathology
  • Male
  • Protein Glutamine gamma Glutamyltransferase 2
  • Transglutaminases / blood
  • Transglutaminases / immunology*

Substances

  • Autoantibodies
  • Protein Glutamine gamma Glutamyltransferase 2
  • Transglutaminases
  • GTP-Binding Proteins

Associated data

  • ClinicalTrials.gov/NCT00677495